PHYS Mark Johnson  Wednesday, March 24, 2010 

599 - pH dependent redox measurements of DNA Photolyase

Caroline Richardson1,, Johannes P.M. Schelvis2, Yvonne M Gindt1. (1) Department of Chemistry, Lafayette College, Easton, PA 18042, United States, (2) Department of Chemistry, Montclair State University, Montclair, NJ 07043, United States

DNA photolyase repairs cyclobutane pyrimidine dimers on DNA using a light-driven electron transfer from a fully reduced FAD (FADH- state) cofactor to the lesion. FADH·, therefore, is an intermediate of the repair process. The FADH- /FADH· reduction potential was measured over a pH range using a spectroelectrochemical titration to further understand the mechanism of the repair.

Wednesday, March 24, 2010 06:00 PM
Physical Chemistry of Ionic Liquids (06:00 PM - 08:00 PM)
Location: The Moscone Center
Room: Hall D


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