MEDI Jeff Zablocki  Sunday, March 21, 2010 

94 - Progress towards the development of a fluorimetric diagnostic for the early detection of trypanosomatid diseases

Ellen D. Beaulieu,, Kenneth J. Gollob, Walderez O. Dutra, Lori L. Olson, Mary J. Tanga. Department of Medicinal Chemistry, SRI International, Menlo Park, CA 94025, United States

We are developing a new point of care diagnostic for the detection of trypanosomatid parasites, based on the fluorimetric detection of a trypanosomal biomarker. Trypanosomal parasites cause three neglected human diseases including Chagas' Disease, Human African Trypanosomiasis, and Leishmaniasis. We are developing a new method for early diagnosis that is based on the detection of a parasite-specific metabolite. Our results show that a unique dye can be used to detect this metabolite from serum extracts by creating a fluorescent molecule upon conjugation suggesting the metabolite may be a good biomarker for the detection of trypanosomal diseases. This diagnostic has several attractive features, including a unique parasitological detection mechanism, low cost, and a low technology detection method that would require minimal technical training. We have synthesized a library of dyes to detect this metabolite and will report our efforts towards developing a diagnostic protocol for the detection of this biomarker.

Sunday, March 21, 2010 07:00 PM
General Poster Session (07:00 PM - 09:00 PM)
Location: The Moscone Center
Room: Hall D


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