ORGN Ahmed Abdel-Magid, Scott Sieburth  Wednesday, August 25, 2010 

904 - Remarkable effect of sulfate additives on the palladium-catalyzed cyanation of aryl chlorides

Michael Shevlin Department of Process Research, Merck Research Laboratories, Rahway, NJ, United States

We have discovered that sulfate additives such as H2SO4 greatly increase the reactivity of palladium catalysts for the cyanation of aryl and heteroaryl chlorides and render them more robust toward adventitious air. Using this method, a wide variety of aromatic and heteroaromatic nitriles were prepared in high yield. Formation of the palladium-ligand complex prior to introduction of the catalyst solution to the reaction mixture is critical for high yielding reactions.

Wednesday, August 25, 2010 03:40 PM
Metal-Mediated Reactions and Syntheses (01:00 PM - 04:40 PM)
Location: Boston Convention & Exhibition Center
Room: Room 204B


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