Welcome Guest

Divisions

Return to: Divisions -> Sessions

 MEDI Joel Barrish  Sunday, March 25, 2012 

Poster Session
General Poster Session - EVE Session
Organizers: Joel Barrish
Duration: 7:00 pm - 9:00 pm
                   
   
 Pub #Presentation Title
 35Mitochondria-targeted gold nanoparticles for combined photothermal and chemotherapy
Andrew L Cooper, Sean Marrache, Shanta Dhar.
 36Hit validation of ERK5 inhibitors: Expectations and challenges
Stephanie M Myers, Ruth H Bawn, Betty Cottyn, Bernard T Golding, Roger J Griffin, Tim Hammonds, Hing Leung, David Newell, Laurent Rigoreau, Ai Ching Wong, Ian R Hardcastle, Celine Cano.
 37Design, synthesis and anticancer activity of artemisinin-combretastatin hybrids
Lémbé K. Ngassam, Maxwell A. Casely-Hayford.
 38Heteroaryl hydroxamic acid derivatives as novel histone deacetylase inhibitors
Fumiyuki Shirai, Koichiro Mukoyoshi, Yasuharu Urano, Yoshiteru Eikyu, Naoki Ishibashi, Yuki Sawada, Kazunori Kamijo, Yoshihiro Kozuki, Shigeki Satoh, Taro Masunaga, Mitsuru Ohkubo, Mitsuaki Ohta, Shinichi Tsukamoto.
 39Discovery of isozyme-selective histone deacetylase inhibitors by click chemistry
Takayoshi Suzuki, Yosuke Ota, Yuki Kasuya, Hidehiko Nakagawa, Naoki Miyata.
 40Design and synthesis of Duocarmycins and Anthramycin-related DNA minor groove alkylaors
Sherif F Hammad, Forrest T Smith.
 411,2,3-Triazole-4-carboxamide as a nucleobase analog
Michael F. Romano, Caroline A. Shaffner, Erland P. Stevens.
 42Discovery of imidazopyridine and imidazopyridazine inhibitors of PI3K
Wooseok Han, Sabina Pecchi, Matthew Burger, Jiong Lan, Aaron Smith, Mark Knapp, Kay Huh, Daniel Lopes De Menezes, Johanna Jansen, Hanne Merritt, Susan Kaufman, Charles Voliva.
 43Structure guided optimization of a fragment hit to a series of imidazopyridine inhibitors of PI3K
Sabina Pecchi, Wooseok Han, Zhi-Jie Ni, Matthew Burger, Aaron Smith, Mark Knapp, Johanna Jansen, Hanne Merritt, Susan Kaufman, Charles Voliva.
 44Optically pure apogossypolone derivative as potent pan-active inhibitor of anti-apoptotic Bcl-2 family proteins
Jun Wei, John L Stebbins, Shinichi Kitada, Rupesh Dash, Dayong Zhai, William J Placzek, Paul B Fisher, John C Reed, Maurizio Pellecchia.
 45Design and synthesis of pyrrolo[3,2-d]pyrimidine HER2/EGFR dual inhibitors: Exploration of novel back-pocket binders
Youichi Kawakita, Hiroshi Banno, Tomohiro Ohashi, Toshiya Tamura, Tadashi Yusa, Akiko Nakayama, Hiroshi Miki, Hidehisa Iwata, Hidenori Kamiguchi, Toshimasa Tanaka, Noriyuki Habuka, Satoshi Sogabe, Yoshikazu Ohta, Tomoyasu Ishikawa.
 46Design, synthesis, and biological evaluation of cyclopropylamine-based LSD1 inhibitors
Daisuke Ogasawara, Takayoshi Suzuki, Rie Ueda, Mohammed Naseer Ahmed Khan, Takuya Matsubara, Koshiki Mino, Hidehiko Nakagawa, Tamio Mizukami, Naoki Miyata.
 47Design, synthesis, and biological activity of JMJD2 histone demethylase inhibitors
Hiroki Ozasa, Takayoshi Suzuki, Shohei Hamada, Koshiki Mino, Hidehiko Nakagawa, Tamio Mizukami, Naoki Miyata.
 48Design, synthesis, and SAR studies of duel FLT-3 and Aurora kinase inhibitors
Hsing-Pang Hsieh, Hui-Yi Shiao, Wen-Hsing Lin, John Tsu-An Hsu, Yu-Sheng Chao.
 49In silico test battery for rapid evaluation of genotoxic and carcinogenic potential of chemicals
Kiril Lanevskij, Liutauras Juska, Justas Dapkunas, Andrius Sazonovas, Pranas Japertas.
 50Novel amino acid derivatives of naproxen for colon cancer chemoprevention
Tarek Aboul-Fadl, Suliman S Al-Hamad, Mohammed K Abdel-Hamid, Hatem A Abdel-Aziz, Abdel-Rahman M Al-Obaid, Jason D Whitt, Bernard D Gary, Adam B Keeton, Gary A Piazza.
 51Novel 4-N-modified gemcitabine analogs
Jesse Pulido, Adam J Sobczak, Heysell Ortiz, Alana Van Dervort, Patricia Theard, Deodutta Roy, Stanislaw F Wnuk.
 52Biomedical research at core synthesis facility of North Dakota State University
Yong-Hua Yang, Gregory R. Cook, Mukund P. Sibi.
 53Discovery of OSI-027: An imidazotriazine-based orally efficacious dual inhibitor of mTORC1 and mTORC2
Hanqing Dong, Shripad V. Bhagwat, David Beard, Apoorba Bharadwaj, Mark A. Bittner, Xin Chen, Heather Coate, Andrew Cooke, Prafulla Gokhale, Jennifer Kahler, Christine Mantis, Mark J. Mulvihill, Bijoy Panicker, Paula A. Tavares-Greco, Brian Volk, Jing Wang, Douglas S. Werner, Yan Yao, Lee D. Arnold, Jonathan A. Pachter, Robert Wild, David Epstein, Andrew P. Crew.
 54New diarylureas and diarylamides possessing 1H-pyrrolo[3,2-c]pyridine scaffold: Design, synthesis, and anticancer evaluation
Mohammed I. El-Gamal, Chang-Hyun Oh, Myung-Ho Jung.
 55Design and synthesis of benzylamine and benzyl ether derivatives as Wnt mimetics to promote stem cell pluripotency: Comparison of carbonyl and oxime or oxime ether functionality
Kevin H. Chen, Edward Laguna, Tyler Routledge, Leslie Kirby, Jason Schott, Nilay Patel, Peter de Lijser.
 56Synthesis and biological evaluation of aminosteroid inhibitors of the inositol phosphatase SHIP1
Dennis R Viernes, Robert Brooks, Sonya Iyer, Sandra Fernandes, William G Kerr, John D Chisholm.
 57Mimicking a protein to inhibit protein-protein interactions: Design and synthesis of peptide-containing drugs to promote pluripotency in stem cells
Karissa Montes, Melchor Alcantara, Katrina Jully, Kevin Chen, Tyler Routledge, Nilay Patel, Peter de Lijser.
 58Development of novel metalloenzyme proinhibitors
Kevin B Daniel, Seth M Cohen.
 59Use of chalcones and its oxime and oxime ether derivatives as drugs for maintaining stem cell pluripotency
Brenda Hinh, Kavita Amin, Elizabeth Shuman, Mikiko Satoh, Tyler Routledge, Nilay Patel, Peter de Lijser.
 60Design and synthesis of mono- and diamides as potential drugs for maintaining stem cell pluripotency
Quynh C. Tran, Tu-Anh Tran, Francis Mision, Luke Hanna, Dereck Ferdaws, SimmerDeep Kaur, Karen Balcazar, Sarah Neumann, Hailey Park, Tyler Routledge, Nilay Patel, Peter de Lijser.
 61Development of point-of-care biosensor: A step forward toward breast cancer diagnosis
Abdel-Nasser M Kawde, Guodong Liu, Khalid Alhooshani, Asim Diab.
 62Synthesis and biological investigation of pegylated adenosine A2A receptor antagonist
Vincent Chevalier, Rhiannon Thomas, Graham B. Jones.
 63Design and synthesis of benzimidazole for DNA intercalation
Alisha J Fisher, Leyte Winfield.
 64Sythesis and evaluation of novel isothiocyanates
Ruthellen H Tornberg, Jared R. Mays, Cody Lensing.
 65High content screening for the development of novel photosensitizers
Mathias O. Senge, Gisela M. Vaz, Anthony Davies.
 66Design, synthesis and insight into the structure-activity relationship of 1,3-disubstituted indazoles as novel HIF-1 inhibitors
Hongchan An, Nam-Jung Kim, Jong-Wha Jung, Hannah Jang, Kyeojin Kim, Young Taek Han, Hyunyoung Moon, Jong-Wan Park, Young-Ger Suh.
 67Synthesis and RP-HPLC monitored hydrolysis of non-natural glucosinolates
Kayla Vastenhout, Jared Mays.
 68New selective nonsteroidal aromatase inhibitors: Synthesis and inhibitory activity of 3-phenylchroman-4-ones
Erica Amato, Kevin Bonfield, Audrey Rivet, Adam McCallum, Stefan Paula, Lili Ma.
 69Development of a new class of aromatase inhibitors: Design, synthesis, and biological activity of 3-phenylchroman-4-one (isoflavanone) derivatives
Adam M McCallum, Erica Amato, Kevin Bonfield, Hannah Agard, James Keeler, Jeffrey Steller, Stefan Paula, Lili Ma.
 70Discovery of 6-arylsulfonyl pyridopyrimidinones as potent and selective PLK2 inhibitors
Muralidhar M Mallireddigari, Vinaykumar Billa, Shashidhar S Jatiani, Stephen C Cosenza, E. Premkumar Reddy, M. V. Ramana Reddy.
 71Novel dimethyl dicarboxylate biphenyl (DDB) analogs as potent cancer chemopreventive agents
Hsin-Yi Hung, Kyoko Nakagawa-Goto, Harukuni Tokuda, Akira Iida, Nobutaka Suzuki, Susan L Morris-Natschke, Kuo-Hsiung Lee.
 72Development of S-trityl L-cysteine based inhibitors of the mitotic kinesin Eg5 with in vivo antitumor activity
James AD Good, Fang Wang, Oliver Rath, Hung Yi Kristal Kaan, Dawid Podgórski, Oliver B. Sutcliffe, Simon P Mackay, Frank Kozielski.
 73Synthesis and biological evaluation of Z-isomer of Rigosertib™ (ON 01910.Na) − a clinical stage (Phase III) multi kinase anticancer agent
Venkat R Pallela, Muralidhar R Mallireddigari, Stephen C Cosenza, Chen Ren, E. Premkumar Reddy, M. V. Ramana Reddy.
 74Design, synthesis and biological study of novel epidermal growth factor receptor kinase (EGFRK) inhibitors
Venkata Subbaiah, Venkat R Pallela, Stephen C Cosenza, Gayathri Panda, Muralidhar M Mallireddigari, E. Premkumar Reddy, M. V. Ramana Reddy.
 75Novel cyano pyridopyrimidines as potent and selective inhibitors of CDK4 and Ark5 kinases
Balaiah Akula, Saikrishna Athuluri, Stephen C Cosenza, Vinay Kumar, E. Premkumar Reddy, M. V. Ramana Reddy.
 76Evaluation of N-acyl sulfonamide prodrug inhibitors of MEK kinase
Jeffrey Ralph, Jerry Adams, Domingos Silva, Yanhong Feng, Peter Martin, Swarupa Kulkarni, Katherine Moss, Cynthia Rominger, Maureen Bleam, Sylvie Laquerre.
 77N-Alkylated diaryl pyrazoles: Selective Aurora kinase inhibitors
Jeffrey Ralph, Yanhong Feng, Domingos Silva, Jerry Adams, Thomas Faitg, Mary Ann Hardwicke, Jamin Wang, Catherine Oleykowski, Melody Diamond, David Sutton, Leo Faucette, Ramona Plant.
 78New inhibitors of cathepsin D containing hydroxyethylamine isosteres
Prashanth Akula, Bharat Guda, Durga Yeramala, Franklin Rahman, Ryan Keefer, Naveen Reddy Kadasala, Lisa Wen, Rose McConnell.
 79New cathepsin B inhibitors containing argininal thiosemicarbazones
Bharat Guda, Durga Yeramala, Prashanth Akula, Keegan Steele, Franklin Rahman, Naveen Reddy Kadasala, Karthik D. Malayala, Jin Jin, Shaozhong Zhang, Lisa Wen, Jenq-Kuen Huang, Rose M. McConnell.
 80Design and synthesis of novel DFG-out RAF/VEGFR2 inhibitors: Synthesis and characterization of a novel imide-type prodrug for improving oral absorption
Masanori Okaniwa, Masaaki Hirose, Takashi Imada, Tomohiro Oohashi, Youko Hayashi, Tohru Miyazaki, Takeo Arita, Masato Yabuki, Akihiko Sumita, Shunichirou Tsutsumi, Keiko Higashikawa, Terufumi Takagi, Tomohiro Kawamoto, Yoshitaka Inui, Bi-Ching Sang, Jason Yano, Kathleen Aertgeerts, Sei Yoshida, Tomoyasu Ishikawa.
 81Synthesis of azanovobiocin derivatives using Cu(I)/Pd(II)-catalyzed C-N bond formation
Steven M Moss, Prattya Nealmongkol, Nopporn Thasana.
 82Synthesis of novel nitrogenous tetracyclic compounds as potential anticancer agents
Shubhashis Chakrabarty, Michael S Croft, Guillermo Moyna.
 83Discovery, design and synthesis of a novel series of non-peptidomimetic inhibitors of XIAP-caspase 9 interactions
Daniel M Allwood, Rebecca M Myers, Frances Richards, Andreas Bender, Colin Watts, Steven V Ley.
 84WITHDRAWN
 85Design and synthesis of quinazoline derivatives as potentially of novel PI-3K inhibitors
Surya K De, Elisa Barile, Coby B Carlson, Vida Chen, Roberta Noberini, Angela Purves, Petra Pavlickova, Li Yang, Russell Dahl, John L Stebbins, Elena B Pasquale, Maurizio Pellecchia.
 86Two modular peptide substrates to identify substrate selective MAPK inhibitors
Mangalika Warthaka, Sunbae Lee, Chunli Yan, Tamer S Kaoud, Pengyu Ren, Kevin N Dalby.
 87Discovery and characterization of Kevetrin™: A small molecule with potent anticancer activity
Siya Ram, Tejindervir S Hiran, Karima Chafai-Fadela, Samantha Rogers, Ashok Kumar, Sylvia Holden, Krishna Menon.
 88Synthesis, spectroscopic characterization and in vitro cytotoxic activities of novel mononuclear Ru(II)complexes
Sreekanth Thota, Imran Mohammad, Jan Balzarini, Erik De Clercq.
 89Predicting DNA-intercalator binding: An application of a new arene-arene stacking parameter
Charles A Johnson, Laura K E Hardebeck, Graham A Hudson, Michael Lewis, Brent M Znosko.
 90Small molecule Mcl-1 pathway inhibitor and ABT-737 synergistically inhibit growth and induce apoptosis
Rajkumar N Rajule, Amarnath N Natarajan.
 91Human farnesyl pyrophosphate synthase: New opportunities for a challenging therapeutic target
Joris Wim De Schutter, Youla S. Tsantrizos, Yih-Shyan Lin, Jaeok Park, Albert Berghuis, Xian Fang Huang, Michael Sebag.
 92Design, synthesis and biological activity of urea derivatives as anaplastic lymphoma kinase inhibitors
Gustav Boije af Gennäs, Luca Mologni, Shaheen Ahmed, Mohanathas Rajaratnam, Oriano Marin, Niko Lindholm, Michela Viltadi, Carlo Gambacorti-Passerini, Leonardo Scapozza, Jari Yli-Kauhaluoma.
 93Novel anti-inflammatory and pro-resolving aspirin-triggered protectin pathway
Nicos A. Petasis, Jeremy W. Winkler, Min Zhu, Nicolas G. Bazan, Charles N. Serhan.
 94Design and synthesis of novel anticancer agents targeting uracil-DNA repair
Nicos A Petasis, Marcos A Sainz, Kevin J. Gaffney, Peter M. Wilson, Robert D. Ladner.
 95Synthesis and biological evaluation of 4-O-methylhonokiol analogs
Da Young Kim, Bit Lee, Hyeju Jo, Min Ho Choi, Sri Hari Galla, Jae-Hwan Kwak, Young-Shin Kwak, Heesoon Lee, Seung-Yong Seo, Jae-Kyung Jung.
 96Amides of xanthurenic acid as zinc-dependent inhibitors of Lp-PLA2
Yi Hu, Emme C. K. Lin, Christopher M. Amantea, Lan M. Pham, Julia Cajica, Eric Okerberg, Heidi E. Brown, Allister Fraser, Lingling Du, Yasushi Kohno, Junichi Ishiyama, John W. Kozarich, Kevin R. Shreder.
 97Azabenzthiazole inhibitors of leukotriene A4 hydrolase
Virginia M. Tanis,
 98Synthesis and activity of folate conjugated didemnin B for potential treatment of inflammatory diseases
Walter A. Henne, Sumith A. Kularatne, Wilfredo Ayala-Lopez, Derek D. Doorneweerd, Torian W. Stinnette, Yingjuan Lu, Philip S. Low.
 99Design and development of new non steroidal anti-inflammatory drugs that inhibit COX-2 enzyme
Wanda I Rodriguez Rivera, Ekkehard Sinn.
 100Structure-activity relationship study of isoxazole-derived LPA1 antagonists
Takashi Yamamoto, Yukie Seki, Taro Nakamura, Koichi Fujita, Sayaka Asari, Yuka Kataba, Koji Ohsumi, Satoshi Iwayama, Hiroyuki Eda, Naoyuki Fukuchi, Chiori Ijichi, Itsuya Tanabe, Makoto Shiozaki, Kuniya Sakurai, Masataka Shoji.
 101Discovery and design of 2-phenylindole-based nitric oxide synthesis inhibitors as potential antiinflammatory and chemopreventive agents
Xufen Yu, Eun-Jung Park, Tamara P Kondratyuk, John M Pezzuto, Dianqing Sun.
 102Lead optimization of a TYK2 selective scaffold
Jun Liang, Steve Magnuson.
 103Chemical and biological properties of nitrogen oxide releasing NSAIDs
Gaurav Bharadwaj, Debashree Basudhar, Yannon Liang, Katrina M Miranda.
 104Substrate analogs as mechanistic probes of nitric oxide synthase
Kristin Jansen Labby, Roman Davydov, Huiying Li, Brian M Hoffman, Thomas L Poulos, Richard B Silverman.
 105Design, synthesis and biological evaluation of novel thiazole derivatives as vascular adhesion pretein-1 inhibitors
Takayuki Inoue, Akira Nagashima, Ayako Moritomo, Tojo Takashi, Masataka Morita, Kousei Yoshihara, Mitsuru Ohkubo, Hiroshi Miyake.
 106Mechanism of inactivation of inducible nitric oxide synthase by amidines
Wei Tang, Richard B. Silverman.
 107Phosphodiesterase inhibitors: Design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory pyrazolo[1,5-a]pyridines with anti-inflammatory and bronchodilatory activity
Koji Ochiai, Naoki Ando, Kazuhiko Iwase, David R Adams, Yasushi Kohno.
 108Design, synthesis, and characterization of a potent and selective subnanomolar bi-dentate JNK inhibitor
Surya K De, John L Stebbins, Vida Chen, Elisa Barile, Angela Purves, Jason F Cellitti, Thomas Machleidt, Barbara Becattini, Megan Riel-Mehan, Li Yang, Russell Dahl, Maurizio Pellecchia.
 109S-Nitrosoglutathione reductase inhibitors for the treatment of diseases
Xicheng Sun, Gary J Rosenthal.
 110Namalide, a natural cyclic peptide and its analogs as carboxypeptidase A inhibitors
Pradeep Cheruku, Alberto Plaza, Jessica L Keffer, Carole A Bewley.
 111Diketopiperazine-based inhibitors of protein-protein interactions
Mariell Pettersson, Petra Båth, Kristina Luthman, Morten Grøtli.
 112Synthesis and utility of novel peptidomimetics containing hydroxyethyl isostere and imodazolidinone
Susann H Krake, Stephen C Bergmeier.
 113Screening vorozole on a series of human liver cytochrome P450s
Melissa A VanAlstine, Joanna Fowler, Lendelle Raymond, Nikita Rayani, Grace Polson, Kylie Sikorski, Ailin Lian.
 114High throughput determination of glutathione binding ability of small molecules with the use of intrinsically fluorescent probes
Megan M. McCallum, Premchendar Nandhikonda, Leggy A. Arnold.
 115Highly efficient 18F-fluorination of diaryliodonium salts
Linlin Qin, Kiel D Neumann, Stephen G DiMagno.
 116Developing chemical probes for the BET bromodomains
David S Hewings, Minghua Wang, Martin Philpott, Oleg Fedorov, Sagar Uttarkar, Panagis Filippakopoulos, Sarah Picaud, Chaitanya Vuppusetty, Brian Marsden, Tom D Heightman, Stefan Knapp, Paul Brennan, Stuart J Conway.
 117Design and synthesis of 8-phenyl-1,2,3,4-tetrahydroisoquinolines as 5-HT7 receptor ligands
Shiau-Chin Wang, Chia-Ying Yang, Ling-Wei Hsin.
 118Synthesis and evaluation of novel heteroaromatic substrates of GABA aminotransferase
Dustin D Hawker, Richard B Silverman.
 119Rational design and evaluation of substituted-pyrimidines as dual cholinesterase and amyloid aggregation inhibitors
Praveen PN Rao, Tarek Mohamed, Jacky CK Yeung, Jerry Yang.
 120WITHDRAWN
 121Nootropics for use in schizophrenia: Dual positive allosteric modulation of α7 nAChR & GABAAR
Thomas A Ford-Hutchinson, Derk Hogenkamp, Ryan Yoshimura, Minhtam Tran, Timothy Johnstone, Edward Whittmore, Hannah Rowlins, Lena Lu, Kelvin Gee.
 122Synthesis and SAR of isothiazolylidene amides as CB2 agonists
Tongmei Li, Arturo Perez-Medrano, Anthony V Daza, George K Grayson, Yihong Fan, Tiffany R Garrison, Betty B Yao, Gin C Hsieh, Prisca Honore, Lanlan Li, Odile El Kouhen, Michael J Dart, Michael D Meyer, William A Carroll.
 1236-Position optimization of tricyclic 4-quinolone-based inhibitors of glycogen synthase kinase-3β: Discovery of nitrile derivatives with picomolar potency
Oana M Cociorva, Bei Li, Tyzoon Nomanbhoy, Qiang Li, Kai Nakamura, Masahiro Nomura, Kyoko Okada, Kazuhiro Yumoto, Marek Liyanage, Melissa C Zhang, Arwin Aban, Anna Katrin Szardenings, John W Kozarich, Yasushi Kohno, Kevin R Shreder.
 124Benzodiazepine specificity of γ-aminobutyric acid (GABAA) receptor subtypes: High-throughput electrophysiological assay on transiently transfected cells
Nina Y. Yuan, James M. Cook, Leggy A. Arnold.
 125Discovery of 5-HT4 receptor partial agonist for the treatment of Alzheimer's disease
Anil Shinde, Ramasastry Kambhampati, Mohammed Abdul Rasheed, Adireddy Dwarampudi, Laxman Kota, Muralimohan Gampa, Padmavathi Kodru, Vinaykumar Tiriveedhi, Sangram Keshri Saraf, Ramkumar Subramanian, Muddukrishna Chillakur, Pradeep Jayarajan, Gopinadh Bhyrapuneni, Ramakrishna Nirogi.
 126Discovery of novel amides: Highly potent and selective histamine H3 receptor antagonists and their procognitive potential
Ramakrishna Nirogi, Anil Shinde, Adireddy Dwarampudi, Amol Deshpande, Ramasastry Kambhampati, Laxman Kota, Muralimohan Gampa, Padmavathi Kodru, Vinaykumar Tiriveedhi, Sangram Keshri Saraf, Vishwottam Kandikere, Renny Abraham, Dhanalakshmi Shanmuganathan, Patnala Murthy.
 127MK-8825: A potent and selective CGRP receptor antagonist with good oral activity in rats
Ian M Bell, Craig A Stump, Joseph G Bruno, Amy Calamari, Christine Fandozzi, Steven N Gallicchio, Amanda L Kemmerer, Eric L Moore, Scott D Mosser, Nova Sain, Donnette D Staas, Mark Urban, Rebecca B White, C Blair Zartman, Christopher A Salvatore, Stefanie A Kane, Samuel L Graham, Joseph P Vacca, Harold G Selnick.
 128Classification of drugs by CNS access: An insight from quantitative blood-brain transport characteristics
Kiril Lanevskij, Pranas Japertas, Remigijus Didziapetris.
 129Probes for narcotic receptor mediated phenomena: Conceputalization, synthesis and pharmacological evaluation of ring-expanded Phenylmorphans
Fuying Li,
 130Synthesis and evaluation of 3-benzylaminomorphinans at the opioid receptors
Anna W. Sromek, John L. Neumeyer, Bin Zhang, Tangzhi Zhang, Jean M. Bidlack.
 131Insights into the structural features of BACE: Comparison of the isozymes
Divya Ramamoorthy, Wayne Guida.
 132Amino-containing analogs of N-thiazolylidene arylcarboximide: Potent, selective cannabinoid CB2-- agonists as novel pain therapeutics
Xueqing Wang, Bo Liu, Jennifer Frost, Steven Latshaw, Meena Patel, Teodozyj Kolasa, William Carroll, Michael Dart, Anthony Daza, George Grayson, Yihong Fan, Loan Miller, Lanlan Li, Bradley Hooker, Odile El-Kouhen, Prasant Chandran Chandran, Anita Salyers, Madhavi Pai, Gin Hsieh, Betty Yao, Michael Meyer.
 133Tetra-alkyl bis-phosphates as bivalent inhibitors of butyrylcholinesterase: Compounds with potential for treatment of Alzheimer's disease
Kim Ngan T Tu, Elise Van Fossen, Nick Spurlock, Omar Gallegos, Robert Esquivel, Nakayama Kensaku, Roger Acey.
 134Synthesis and SAR analysis of 1,3-disubstituted isopropanols as novel scaffold for β-secretase inhibition
Arun Babu Kumar, Jordan Anderson, Roman Manetsch.
 135Modeling, synthesis and biological evaluation of Retinoid-X-Receptor (RXR) selective agonists with potential to treat Alzheimer's disease
Carl E Wagner, Peter W Jurutka, Arjan van der Vaart, Pamela A Marshall, Luis A Montano, Gary Landreth, Paige E Cramer.
 136Discovery of truncated (N)-methanocarba nucleosides as A1 adenosine receptor agonists
Dilip K Tosh, Khai Phan, Francesca Deflorian, Qiang Wei, Zhan-Guo Gao, Kenneth A Jacobson.
 137Synthesis and structure-activity relationship of Tc/Re 2-arylbenzothiazoles as β-amyloid imaging agents
Jinhe Pan, N Scott Mason, Manik L Debnath, Chester A Mathis, William E Klunk, Kuo-Shyan Lin.
 138Synthesis of trisubstituted-1,2,4-triazoles as somatostatin subtype-4 receptor (sst4) ligands
Iman Daryaei, Michael Crider, Karin Sandoval, Ken Witt.
 139Divergent SAR for carboxamido-substituted kappa opioid receptor antagonists
Yigong Bu, Jean M. Bidlack, Dana J. Cohen, Qun Lu, Mark P. Wentland.
 140Discovery of fused oxadiazines as gamma secretase modulators
Xianhai Huang, Zhaoning Johnny Zhu, Xiaoxiang Liu, Wei Zhou, Hongmei Li, Mihirbaran Mandal, Zhongyue George Sun, Monica Vicarel, Xiaohong Zhu, Robert Aslanian, John Clader, Michael Czarniecki, William Greenlee, Anandan Palani, Mary Cohen-Williams, Lynn Hyde, Lixin Song, Lili Zhang, Inhou Chu.
 141Synthesis, characterization, antioxidant and antimicribial activities of some novel pyrazoline derivatives
Rajeshwar Yerra, Manasa Udugula, Mohammad Imran, Sreekanth Thota.
 142Synthesis and antimycobacterial assessment of 2-methylaristeromycins
Sherif F Hammad, Stewart T Schneller.
 143High-throughput screening, virtual screening and rational drug design identify potent inhibitors for Pseudomonas aeruginosa RmlA
Aurijit Sarkar, Mary Gardiner, Magnus S Alphey, David Gray, James Naismith, Ruth Brenk.
 144Design and synthesis of anti-trypanosomal drugs based on the 1,4,5,6 tetrahydropyrrolo [3,4-c]pyrazole scaffold via target repurposing
Stefan O Ochiana, Vidya Pandarinath, Zhouxi Wang, Larry Ruben, Mary Jo Ondrechen, Michael P Pollastri.
 145Identification of small-molecule inhibitors of the trypanosomal kinase TbAUK1 based on comparative modeling
Zhouxi Wang, Stefan O Ochiana, Vidya Pandarinath, Larry Ruben, Mary Jo Ondrechen, Michael P Pollastri.
 1462,4-diaminoquinazolines as anti-leishmanials
Kurt S Van Horn, Xiaohua Zhu, Trupti Pandharkar, Brian Vesely, Sihyung Yang, Michael Zhuo Wang, Dennis Kyle, Karl Werbovetz, Roman Manetsch.
 147First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the leishmania topoisomerase IB enzyme
Nestor M. Carballeira, Michelle Cartagena, Fengyu Li, Zhongfang Chen, Christopher F. Prada, Estefania Calvo-Alvarez, Rosa M. Reguera, Rafael Balana-Fouce.
 148Discovery of new inhibitors of Trypanosoma cruzi GAPDH: Protein-based pharmacophore, virtual screening, and biochemical evaluation
Fernando V. Maluf, Adriano D. Andricopulo, Glaucius Oliva, Rafael V. C. Guido.
 1493D-QSAR approach on imidazole-dioxolane analogs with anti-plasmodium activity: A strategic design of novel antimalarial agents.
Fernando Vasconcelos Maluf, Evandro J. Mulinari, Celia R. S. Garcia, Adriano D. Andricopulo, Glaucius Oliva, Rafael V. C. Guido.
 150Synthesis and structure activity relationship of pyrazole derivatives as anti-tuberculosis agents
Jinwoo Lee, Valentina Dona, Helena I. Boshoff, Clifton E. Barry.
 151Inhibition of adenosylhomocysteine hydrolase of Trichomonas vaginalis with 9-(2-deoxy-2-fluoro-β,D-arabinofuranosyl)adenine
Aaron Au, Ajit Shokar, Steven An, Kirkwood M Land, Jessica Zayas, Stanislaw F Wnuk.
 1528-Triazolylpurines as potential t-RNA synthetase inhibitors
David Bliman, Itedale Namro Redwan, Morten Grøtli.
 153Design, synthesis and biological evaluation of hybrid–type derivatives of myxopyronin as inhibitors of bacterial RNA polymerase
Fumika Yakushiji, Reiko Okamoto, Yuki Kunoh, Yuko Miyamoto, Yuri Yamazaki, Yoshio Hayashi.
 154Design, synthesis, and biological evaluation of new species-selective inhibitors of aspartate semialdehyde dehydrogenase
Amarjit Luniwal, Lin Wang, Paul W. Erhardt, Ronald E Viola.
 155Design, synthesis and biological evaluation of 2-arylbenzimidazoles targeting intracellular parasites Chlamydia pneumoniae and Leishmania donovani
Leena Keurulainen, Olli Salin, Antti Siiskonen, Pia Vuorela, Jari Yli-Kauhaluoma, Paula Kiuru, Nina Sacerdoti-Sierra, Abedelmajeed Nasereddin, Jan Marco Kern, Teppo Leino, Matthias Maass, Charles L. Jaffe.
 156Identification of cyclic γ-AApeptides with potent and broad-spectrum antimicrobial activity
Haifan Wu, Shruti Padhee, Youhong Niu, Ge Bai, Yaqiong Li, Chuanhai Cao, Jianfeng Cai.
 157Novel and selective inhibitor of bacterial N5-carboxy-5-aminoimidazole ribonucleotide mutase (N5-CAIR mutase)
Maria V. Fawaz, Steven M. Firestine.
 158Discovery of antibacterial leads targeting isoprenoid biosynthesis: A knowledge and structure-based approach
Yonghui Zhang, Fu-Yang Lin, Ke Wang, Kai Li, Yi-Liang Liu, Wei Zhu, Mary Hensler, Ohn A Chow, Victor Nizet, Eric Oldfield.
 1592,4-Diaminoquinazolines as antibacterials
Kurt S Van Horn, Whittney Burda, Lindsey Shaw, Roman Manetsch.
 160Design and synthesis of novel antifolates as potent inhibitors of Bacillus anthracis
Kishore Viswanathan, Jennifer Beierlin, Amy Anderson, Dennis Wright.
 161WITHDRAWN
 162Controlling bacterial behavior by bicyclic brominated furanones with reduced toxicity
Sijie Yang, Fei Cheng, Yan-Yeung Luk.
 163Discovery and development of highly potent inhibitors of Mycobacterium tuberculosis growth in vitro
Warren S. Weiner, Frank Schoenen, Apurba Dutta, Jeffrey Aubé, E. Lucile White, Clinton Maddox, Ntsang Miranda Nebane, Nichole A. Tower, Sara McKellip, Anna Manuvakhova, Lakshmi Reddy, Melinda Sosa, Lynn Rasmussen, Kanupriya Whig, Subramaniam Ananthan, Shichun Lun, William Bishai.
 164Antibacterial properties of selected herbs on Escherichia coli and Streptococcus aureus
Aaron Ahn, Brian Phung, Lily Nguyen, Austin Li, Erica Fradinger, Priscilla Bell.
 165Development of new non-toxic HCV inhibitors with high efficacy and good PK
Zheng-Yun James Zhan,
 166Novel HCV NS3/4A protease inhibitors with tetrazoyl P* groups
Guoqiang Wang, Ying Sun, Lijuan Jiang, Xiang Lu, The-Uyen Phan, Zhigang Chen, Keith K McDaniel, Dale J. Kempf, Yat Sun Or.
 167SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity
James R Burgeson, Dongcheng Dai, Amy Moore, Jordan K Boutilier, Natasha Cerruti, Dima Gharaibeh, Shanthakumar R Tyavanagimatt, Sean M Amberg, Robert D Allen III, Dennis E Hruby.
 168Development of novel small molecule inhibitors of alphavirus replication
Scott J Barraza, Janice A Sindac, Kyle Bolduc, Bryan Yestrepsky, Richard F Keep, David J Miller, Scott D Larsen.
 169Discovery of novel inhibitors of HCV NS5A and proof of concept study in an HCV-infected chimpanzee
David A. DeGoey, David A. Betebenner, David J. Grampovnik, Nobuhiko Iwasaki, Dachun Liu, John K. Pratt, Michael D. Tufano, Wenping He, Preethi Krishnan, Tami J. Pilot-Matias, Kennan C. Marsh, Akhteruzzaman Molla, Dale J. Kempf, Clarence J. Maring.
 170Small molecule anti-virals against western equine encephalitis virus
Janice A Sindac, Scott Barraza, Kyle Bolduc, Bryan Yestrepsky, David Irani, David Miller, Scott Larsen.
 1716,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors
Xue Zhi Zhao, Kasthuraiah Maddali, Steven J. Smith, Mathieu Metifiot, Stephen Hare, Christophe Marchand, Peter Cherepanov, Stephen H. Hughes, Yves Pommier, Terrence R. Burke, Jr..
 172Synthesis and biological evaluation of West Nile Virus NS2B-NS3 protease inhibitors
Sanjay Samanta, Lim Ting Liang, Yulin Lam.
 173Multiple in silico models for the inhibition of cytochrome P450 (CYP3A4)
Tiago Moda, Raphael Meneghello, Adriano Andricopulo.
 174Are top-selling small molecule drugs compliant with state-of-the-art guidelines for current medicinal chemsitry?
Morten Jørgensen, Andreas Ritzén, Laurent David.
 175Sequence, structure, and function of GPCRs
Amy Y Shih, Taraneh Mirzadegan.
 176Fragment-based drug design towards the advancement of selective and potent metalloenzyme inhibitors
Jessica L Fullagar, Seth M Cohen.
 177Information analysis in biotherapeutics research
Hugo O. Villar, Mark R. Hansen, Eric Feyfant.
 178CoMFA and CoMSIA studies of hexahydropyrimidine derivatives
Adeayo O Ajala, Cosmas O Okoro.
 179New approaches to the chemical synthesis of citronellol type componds useful as enzyme inhibitors
Edward J Parish, Hiroshi Honda, Yu-Chen Lo, Yuli E Honda.
 180New approaches to chemical syntheses of alkyl and alkenyl phenols
Jiann-Tsyh Lin, Hiroshi Honda.
 181Facile synthesis of sulfonyl fluorides
Jiajia Dong, K. Barry Sharpless.
 182T3P®: Novel applications of this green reagent
James A. Schwindeman, Richard Wisdom, Juergen Brockmann.
 183Allylic and benzylic oxidations of steroids with pyridinium chlorochromate and pyridinium dichromate
Edward J Parish, Jiann-Tsyh Lin, Hiroshi Honda.
 184Direct synthesis of tetrahydroquinazolines
G. K. Surya Prakash, Attila Papp, Thomas Mathew, George A. Olah.
 185Rigid amine-containing pyrrolidinones as CB1 antagonists
Jessica M. Garcia, V. Kiran Vemuri, Alexandros Makriyannis.
 186Discovery of MK-4256, a subtype selective SSTR antagonist as a potential treatment of type-2 diabetes
Shuwen He, Zhixiong Ye, Quang Truong, Shrenik Shah, Wu Du, Liangqin Guo, Peter H. Dobbelaar, Zhong Lai, Jian Liu, Tianying Jian, Hongbo Qi, Raman K. Bakshi, Qingmei Hong, James Dellureficio, Alexander Pasternak, Zhe Feng, Reynalda deJesus, Lihu Yang, Mikhail Reibarkh, Scott A. Bradley, Mark A. Holmes, Richard G. Ball, Rebecca T. Ruck, Mark A. Huffman, Frederick Wong, Koppara Samuel, Vijay B. Reddy, Stan Mitelman, Sharon X. Tong, Gary G. Chicchi, Kwei-Lan Tsao, Dorina Trusca, Margaret Wu, Qing Shao, Maria E. Trujillo, George J. Eiermann, Cai Li, Bei Zhang, Andrew D. Howard, Yun-Ping Zhou, Ravi P. Nargund, William K. Hagmann.
 187Synthesis and evaluation of substituted chroman-4-one and chromone derivatives as SIRT2 selective inhibitors
Tina Seifert, Maria Fridén-Saxin, Karin Nilsson, Tiina Suuronen, Elina Jarho, Kristina Luthman.
 188Inhibitor of 3-hydroxy-3-methylglutary coenzyme A reductase: Synthesis and activities of 24-ketolanosterol
Edward J Parish, Yu-Chen Lo, Hiroshi Honda.
 189Discovery of oral AMPK direct activators for the treatment of diabetes
Olivier Mirguet, Anne Bouillot, Alain Daugan, Nicolas Faucher, Nérina Dodic, Stéphane Sautet, Delphine Delannée, Jérôme Toum, Alain Laroze, Frédéric Donche, Catherine Clément, Van-Loc Nguyen, Olivier Pineau, Celine Marques, Yann Lamotte, Franck Martin, Myriam Ajakane, Benjamin Beaufils, Yann Dudit, Pascal Huet, Lionel Trottet, Pascal Grondin, Yannick Saintillan, Edwige Nicodeme.
 190Discovery of SIRT2-selective inhibitors
Hideyuki Sawada, Takayoshi Suzuki, Erica Imai, Mohammed Naseer Ahmed Khan, Hidehiko Nakagawa, Naoki Miyata.
 191Discovery and optimization of 1,5-diarylpyrazole-4-carboxamides as novel CB-1 antagonists
Annapurna Pendri, Dharmpal S Dodd, Zheming Ruan, Jing Chen, MaryEllen Cvijic, Rose A. Baska, Liya Kang, Neil T Burford, Chongqing Sun, Kenneth E Carlson, William R Ewing, Samuel W Gerritz.
 192Small molecule inhibitors of Ghrelin O-acyl transferase
Ryan A Hollibaugh, HaiXia Liu, Nora Elmajian, Ryan Quiroz, Patrick G Harran.
 193Discovery of novel (−)-Cercosporamide derivatives as selective PPARγ modulators
Akihiro Furukawa, Tsuyoshi Arita, Takehiro Fukuzaki, Makoto Mori, Takeshi Honda, Susumu Satoh, Kenji Wakabayashi, Shinko Hayashi, Yumi Matsui, Kazushi Araki, Masanori Kuroha, Jun Tanaka, Satoko Wakimoto, Jun Ohsumi, Kouichi Nakamura.
 194New cathepsin K inhibitors containing argininal thiosemicarbazones
Durga Yeramala, Bharat Guda, Prashanth Akula, Soe Tha, Franklin Rahman, Naveen Reddy Kadasala, Karthik Malayala, Jin Jin, Shaozhong Zhang, Lisa Wen, Jenq-Kuen Huang, Rose M. McConnell.
 195WITHDRAWN
 196Development of fluorescent probes for the vitamin D receptor and their application as screening tools and the biological probes
Premchendar Nandhikonda, Alexander Leggy Arnold.
 197Discovery of a novel 2-spiro-proline derivative as a novel steroid mimetic scaffold for the potent inhibition of 11β-HSD1
David M Burns, Chunhong He, Yanlong Li, Maryanne B Covington, Gregory Hollis, Reid Huber, Brian Metcalf, Wenqing Yao.
 198Discovery of amidines as a novel class of potent and selective 11β- hydroxysteroid dehydrogenase Type 1 inhibitors
Meena V. Patel, Sridhar Peddi, Jeffrey J. Rohde, Udo E. W. Lange, Wilfried Hornberger, Gisela Backfisch, Mohamad Shebly, Peer Jacobson.
 199Progress towards the use of 1,2,4-triazoles as inhibitors of plasminogen activator inhibitor-1
Greg A. Abernathy, Mark Warnock, Daniel A. Lawrence, Cory D. Emal.
 200Boron-based Rho-associated kinase (ROCK) inhibitor: A novel approach to interact with the hinge region and the structure-activity relationships
Tsutomu Akama, Yasheen Zhou, David Sullivan, Richard Kimura, Fernando Rock, Manisha Mohan, Chen Dong, Yong-Kang Zhang, Yvonne Freund, Jacob Plattner, Kurt Jarnagin.
 201Cooperativity among hydrogen bonds in ligand-thrombin complexes: Improving from nanomolar to picomolar
Maan T Khayat, Adam J Biela, Gerhard Klebe, David G Hangauer.
 202Novel, orally bioavaliable adenosine A1 receptor agonists with antinociceptive effects in mice
Ilia Korboukh, Joe Rittner, Amarjit S. Randhawa, Emily A. Hull-Ryde, Stephen V. Frye, William P. Janzen, Mark J. Zylka, Jian Jin.
 203Novel synthesis and biological evaluation of indenoindolones as potent anticancer agents that induce major apoptosis in G1 phase
Maneesh Kashyap, Sankar Guchhait, Chanakya N. Kundu.
 204Structure based design, synthesis and biological evaluation of Ɣ-lactam based HDAC inhibitors for cancer chemotherapy
Chulho Lee, Eunhyun Choi, Gyoonhee Han.
 205H2O2-inducible DNA cross-linking agents: Targeted anticancer prodrugs
Sheng Cao, Xiaohua Peng.
 206Synthesis of heterocyclic aryl sulfones and the investigation of their potential therapeutic uses
Taylor Meek, J. McKee, M. Zanger.
 207Synthesis and adenosine receptor binding studies of some novel hetero-fused pyrimidines
Raghu Prasad, Murty D., Khasim S., Pran Kishore D..
 208WITHDRAWN
 209Inhibition of COX-2 and ASIC-3 by structural analogs of diclofenac
Tyler Rose, Daniel Williams, Kyle Hansen, Ronald McEwen, Emmanuel Deval, Eric Lingueglia.
 210Development of novel P2X3 / P2X2/3 receptor antagonists for the treatment of pain and urinary dysfunction
Adam J. Davenport, Christopher Stimson, Jonathan Savidge, Claudia Albrecht, Andreas Ebneth, Andrea Cesura, David Hallett.
 211Development of GABAB receptor positive modulators for nicotine dependence
Katarzyna Kaczanowska, M.G. Finn.
 212DMPK driven optimisation of potent histamine H3R antagonists for the treatment of CNS disorders
Adam J. Davenport, Mark J. Gemkow, Andrea Cesura, Wayne Thomas, David Hallett.
 213Molecular basis of biased signaling in β2-adrenergic receptor by 19F-NMR
Jeffrey J Liu, Reto Horst, Vsevolod Katritch, Raymond C. Stevens, Kurt Wüthrich.
 214Human H1 receptor studies: Homology model validation, docking and mutagenesis
Tania C. Cordova-Sintjago, Lijuan Fang, Martijn Bruysters, Rob Leurs, Raymond Booth.
 215WITHDRAWN
 216Being different: Industrial-academic alliances for individual approaches to computer-aided drug design
Matthias Rarey,
 217Novel tricks for legacy tasks: Probing the reaction mechanism by mass spectrometric identification of supramolecular adducts
Naisargee Parikh, Asit K. Chakraborti.
 218Hydrogel/calcium phosphate nanocomposites with high mechanical strength: Aiming to bone substitute materials
Dujin Wang,



 MEDI Joel Barrish  Wednesday, March 28, 2012 

Poster Session
General Poster Session - EVE Session
Organizers: Joel Barrish
Duration: 7:00 pm - 10:00 pm
                   
   
 Pub #Presentation Title
 297Design and synthesis of DDX3 inhibitors as anticancer agent
Atul N Kondaskar, Shilpi Kondaskar, Ramachandra Hosmane, James Fishbein.
 298Surface enhanced Raman spectroscopy for the study of anticarcinogenic activity of different medicinal plants
Zarielys Feliciano-Santiago, Nilka M. Rivera-Portalatin.
 299Development and optimization of a cell-based assay to determine intracellular concentrations of bivalent SMAC mimetics
Liu Liu, Xiaoqin Li, Haiying Sun, Jianfeng Lu, Duxin Sun, Shaomeng Wang.
 300Structure-based design, synthesis and evaluation of a potent, dual inhibitors of Bcl-2 and Bcl- XL with in vivo activity
Jianfang Chen, Haibin Zhou, Angelo Aguilar, Liu Liu, Longchuan Bai, Chao-Yie Yang, Donna McEachern, Jennifer Meagher, Jeanne Stuckey, Shaomeng Wang.
 301Redesign of podophyllotoxin
Nikolai M. Evdokimov, Liliya V. Frolova, Alexander Kornienko, Igor V. Magedov.
 302Peptide nanorod: A novel drug carrier
Mona Oumais, Aparna Shinde, Katarzyna Slowinska.
 303Synthesis and evaluation of novel inhibitors of MEF2
Nicos A. Petasis, Jamie A. Jarusiewicz, Kevin J. Gaffney, Nimanthi Jayathilaka, Xiao Lei, Lin Chen.
 304Structural and chemical basis for the antimetastatic properties of a series of migrastatin analogs
Ricardo N Santos, Simone M Duarte, Rafael V C Guido, Luiz C Dias, Glaucius Oliva, Adriano D Andricopulo.
 305Analytical and biochemical studies of the DNA damage produced by platinum-acridines and its recognition by the DNA processing enzymes
Jimmy Suryadi, Xin Qiao, Gregory L. Kucera, Ulrich Bierbach.
 306Synthesis and biological characterization of a novel platinum-pyrrole hybrid antitumor agent
Benjamin M Fontaine, Xin Qiao, Jimmy Suryadi, Gregory L Kucera, Ulrich Bierbach.
 307Development and evaluation of novel conjugation chemistries for the targeted delivery and cellular imaging of potent platinum-acridine anticancer agents
Song Ding, Xin Qiao, Gregory L Kucera, Ulrich Bierbach.
 308Design of 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors
Wanessa F. Altei, Livia B. Salum, Louise D. Chiaradia, Marlon N. S. Cordeiro, Evelyn Winter, Bruno Mattei, Rafael R. Canevarolo, Carolina Souza, Hikmat N. Daghestani, Maria C. S. Silva, Tânia B. Creczynski-Pasa, José A. Yunes, Rosendo A. Yunes, Ricardo J. Nunes, Billy W. Day, Andreas Vogt, Adriano D. Andricopulo.
 309Optimization of thiazole analogs of resveratrol for induction of quinone reductase 1 (QR1)
Abdelrahman S Mayhoub, Laura Marler, Tamara P. Kondratyuk, Eun-Jung Park, John M. Pezzuto, Mark Cushman.
 310Novel 1,4-naphthoquinone derivatives designed as multifunctional small molecules to target non-small cell lung cancer
Rajsekhar Guddneppanavar, Amanda J Pickard, Tiffany K West, Ulrich Bierbach, Gregory L Kucera.
 311WITHDRAWN
 312Investigating the structural criteria for Icmt inhibition through design and synthesis of FTA-triazole based inhibitors
Liza Shrestha, Joel A Bergman, Kalub Hahne, Christine A Hrycyna, Richard A Gibbs.
 313Design, synthesis, and biological evaluation of novel frame-modified geranylgeranyl pyrophosphate analogs
Kayla J Temple, Richard A Gibbs.
 314Keeping out of the kinase domain: Structure–activity relationship (SAR) studies of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione, a potent extracellular signal-related kinase-2 (ERK2) docking domain inhibitor
Kwan-Young Jung, Kerrick Nevels, Shilpa Worlikar, Jamal Chauhan, Sarice Smith, Jeremy L Yap, Sagar Shukla, Joseph Slattery, Mary Ensey, Alexander D MacKerell, Paul Shapiro, Steven Fletcher.
 315Design, synthesis, and studies of novel survivin inhibitors
Somsundaram N Chettiar, In-Hee Park, James Cooley, Deepak Bhasin, Pui Kai Li, Arnab Chakravarti, Jacob Naduparambil, Chenglong Li.
 316Discovery of orally active selective inhibitors of Plk1
Joanne L Pinder, Steven Durrant, Simon Everitt, Michael Mortimore, Shazia Keily, Ronald Knegtel, Michael O'Donnell, Guy Brenchley, Jean-Damien Charrier, Julian Golec, David Kay, Chau Mak, Sharn Ramaya, Alistair Rutherford, John Studley, Anisa Virani, Peter Weber, Stephen C Young.
 317New structural templates for kinase inhibition
Daren Fearon, Keith Jones, Richard Bayliss, Vasillios Bavetsias.
 318Small molecule inhibitors of the c-Myc–Max protein–protein interaction: Targeting the intrinsically disordered (ID) form of c-Myc
Jeremy L. Yap, Kwan-Young Jung, Paul Shapiro, Steven Fletcher.
 319Structure-activity relationship studies of new and highly potent small molecule Bcl-2/Bcl-xL inibitors
Angelo Aguilar, Haibin Zhou, Jianfang Chen, Liu Liu, Longchuan Bai, Chao-Yie Yang, Donna McEachern, Jennifer Meagher, Jeanne Stuckey, Shaomeng Wang.
 320Bromoalkyloxy derivatives of combretastatin A4: Synthesis and biological evaluation.
Lembe K Ngassam, Edward Anning, Kweku Agyekum, Collins Acquah, Maxwell A Casely-Hayford.
 321New synthesis approach for the preparation of a diverse library of acridine based telomerase inhibitors
Rajesh Komati, Branko S Jursic.
 322Design, synthesis and biological evaluation of substituted sulfonamido-1-hydroxynaphthalene compounds as novel small-molecule Mcl-1 inhibitors
Fardokht A Abulwerdi, Chenzhong Liao, Ahmed Mady, Julie Di Bernardo, Azmi Asfar, Tomek Cierpicki, Jeanne Stuckey, Hollis D Showalter, Ramzi Mohammad, Zaneta Nikolovska-Coleska.
 323Structure-based design of a new class of potent Bcl-2/Bcl-xL inhibitors
Habin Zhou, Jennifer Meagher, Liu Liu, Longchuan Bai, Jianfang Chen, Angelo Aguilar, Donna McEachern, Chao-Yie Yang, Qian Cai, Xin Cong, Jeanne Stuckey, Shaomeng Wang.
 324Synthesis of pheophorbide-a conjugates with anticancer drugs as potential cancer diagnostic and therapeutic agents
Hyun You, Bo-Kyoung Kim, Jin-Hee Park, Young-Hwan Jung, Hyo-Eun Yoon, Jung-Hoon Yoon, Hyojin Ko, Yong-Chul Kim.
 325Synthesis of potent and selective Autotaxin inhibitors
Kai Schiemann, Wolfgang Staehle, Melanie Schultz, Dirk Wienke, Friedhelm Bladt, Michael Busch, Astrid Zimmermann, Stefan Hecht, Djordje Musil, Ingo Kober, Sandra Krug, Katharina Ostheimer, Zeljko Lukavski.
 3263,5-Dimethylisoxazoles inhibit the bromodomain-histone protein-protein interaction
David S Hewings, Minghua Wang, Martin Philpott, Oleg Fedorov, Sagar Uttarkar, Panagis Filippakopoulos, Sarah Picaud, Chaitanya Vuppusetty, Brian Marsden, Tom D Heightman, Stefan Knapp, Paul Brennan, Stuart J Conway.
 327Design and synthesis of 8-substituted purines as inhibitors of Nek2 kinase
Christopher J Matheson, Wynne Aherne, Richard Bayliss, Kathy Boxall, Celine Cano, Bernard T Golding, Ian R Hardcastle, Corinne Mas-Droux, David R Newell, Lan Zhen Wang, Roger J Griffin.
 328Exploratory data analysis of alkylphosphocholines as antitumor agents
Matheus Malta de Sá, Silvestre Massimo Modestia, Kerly Fernanda Mesquita Pasqualoto, Carlota de Oliveira Rangel-Yagui.
 329Effects of histone deacetylase inhibitors on the non-small cell lung carcinoma cell line A549
Pinar O Eser, Bryan D. Owens, Amanda M. Del Rosario, Forest M. White.
 330Evolution and structure activity relationship of a series of potent RSK2 inhibitors
Abran Costales, Mika Lindvall, Brent Appleton, Elizabeth Ornelas, Savithri Ramurthy, Jiong Lan, Sharadha Subramanian, Rama Jain, Gordana Atallah, Michelle Tetalman, Lina Setti, Paul Feucht, Bob Warne, Laura Doyle, Steven Basham, AB Jefferson, Cynthia Shafer.
 331Synthesis of FlavinMonoNucleotide analogs targeting noncovalent interactions with PEBP/RKIP protein
Luigi A Agrofoglio, Zhili Zhang, Ozkan Sari, Vincent Roy, Martine Cadene, Lucie Jaquillard, Guillaume Gabant.
 332Design of novel imidazopyridine Type II B-RAFV600E inhibitors
Aaron Smith, ZJ Ni, Daniel Poon, Zilin Huang, Zheng Chen, Qiong Zhang, Hanne Merritt, Kevin Shoemaker, John Chang, Sue Kaufman, Kay Huh, Jeremy Murray, Brent Appleton, Takanori Kanazawa, Hanneke Jansen, Darrin Stuart, Cynthia M Shafer.
 333Development of a novel synthetic route to highly potent and efficacious 5,6-dihydroimidazo[1,5-f]pteridine-7-carbonitrile inhibitors of polo-like kinase-1
Benjamin Jones, Andre Kiryanov, Srinivasa Reddy Natala, Christopher McBride, Jeffrey Stafford, Sheldon Cao, Takashi Ichikawa.
 334Selective histone deacetylase inhibition by 3-hydroxy-pyridin-2-thione based zinc binding group
Quaovi H Sodji, Vishal Patil, James Kornacki, Milan Mrksich, Adegboyega Oyelere.
 335Discovery of a novel series of potent sphingosine kinase 1 and 2 dual inhibitors
Yihong Li, Matthew Brown, Mike Schmitt, Sheldon Wang, Maggie Wanska, Richard Connors, Frank Kayser, Xiaoshan Min, Sheree Johnstone, Bill Romanow, Zhulun Wang, Mario Cardozo, Nigel Walker, Brendon Frank, Shyun Li, Holger Wesche, Shanling Shen, Mariwil Wong, Shawn Jeffries, Matthew Plant, Kurt Morgenstern, Guifen Xu, Timothy Carlson, Karen Rex, Darin Gustin.
 336Structure based design and SAR development of 5,6-dihydroimidazolo[1,5-f]pteridine derivatives as novel polo-like kinase-1 inhibitors
Andre Kiryanov, Benjamin Jones, Srinivasa Reddy Natala, Christopher McBride, Zhe Nie, Victoria Feher, Betty Lam, Yan Liu, Kouhei Honda, Noriko Uchiyama, Tomohiro Kawamoto, Yuichi Hikichi, Lilly Zhang, David Hosfield, Robert Skene, Hua Zou, Jeffrey Stafford, Sheldon Cao, Takashi Ichikawa.
 337Studies toward the synthesis of spiroisoxazolines
Erick Ellis,
 338Design, synthesis, and testing of novel histone demethylase inhibitors as epigenetic modulators
Boobalan Pachaiyappan, Shiv K. Sharma, Ross J. Beattie, Allison Hanson, Stuart Hazeldine, Nora Steinbergs, Robert A. Casero, Jr., Patrick M. Woster.
 339Synthesis and biophysical evaluation of thiazole orange derivatives as DNA G-quadruplex binding ligands
Dazhou Yang, Wanbo Liu, Liang Xue.
 340WITHDRAWN
 341Tetrasubstituted phenanthrolines as potent G-quadruplex stabilizers
Anders Foller Larsen, Trond Ulven.
 342Orally bioavailable Smac mimetics as antagonists of IAP proteins
Haiying Sun, Jianfeng Lu, Liu Liu, Chao-Yie Yang, Donna McEachern, Shaomeng Wang.
 343Structure-based development of biovailable polo-like kinase 1 (Plk1) polo-box domain-binding peptides
Wenjian Qian, Jung-Eun Park, Fa Liu, Dan Lim, Andrej Scharow, Thorsten Berg, Michael B Yaffe, Kyung S Lee, Terrence R Burke, Jr..
 344Synthesis of carbon-11-labeled chromen-4-one derivatives as new potential PET agents for imaging of DNA-dependent protein kinase in cancer
Mingzhang Gao, Min Wang, Qi-Huang Zheng.
 345Design and synthesis of small-molecule radiotracer prototypes for imaging EGFR and HER2 using PET and SPECT
Emily B. Corcoran, Robert N. Hanson.
 346Synthesis and biological evaluation of EGFR /HER-2 inhibitors: Analogs of 5-substituted-4-anilinoquinazoline and 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile – screening for development of novel PET tracers
William H Bisson, Surekha Pimple, Osman Ratib, Leonardo Scapozza, Yann Seimbille.
 347Discovery of potent non-ATP competitive MK2 inhibitors
Dong Xiao, Anand Palani, Robert Aslanian, Xianhai Huang, Sylvia Degrado, Michael Sofolarides, Xiao Chen, Wei Zhou, Ashwin Rao, Zhuyan Guo, James Fossetta, Fang Tian, Daniel Lundell, Peter Spacciapoli, Charles Whitehurst.
 348Docosahexaenoic acid analogs as imaging probes for lipid mediator pathways
Anne-Marie Finaldi, Nicos A. Petasis.
 349WITHDRAWN
 350Heteroaryl imidazolone derivatives as JAK inhibitors
Jacob Gonzalez, Elena Gomez, Paul Robert Eastwood, Jordi Bach, Adela Orellana, Cristina Balague, Elena Calaf, Estrella Lozoya.
 351Synthesis and biological evaluation of α,β-unsaturated lactones as potent immunosuppressive agents
Sun-Mi Lee, Won-Gil Lee, Joong-Heui Cho, Yun-Jin Lee, Yong-Chul Kim, Hyojin Ko.
 352Structure-activity relationships and optimization of 3,5-dichloropyridine derivatives as novel P2X7 receptor antagonists
Won Gil Lee, Jin Hee Park, So Duck Lee, Jeong-Hyun Kim, Yong-Chul Kim.
 353Immunosuppressive effects of subglutinol derivatives
Won Gil Lee, Hyun You, Sun Mi Lee, Seong Hwa Kwak, Hyung Su Kim, Ji Yong Hong, Yong Chul Kim.
 354Brain penetrant Jun kinase inhibitors for the treatment of multiple sclerosis
Laura Barden, Gurpreet Bhatia, Luis Castro, Raymond Chung, Paschalis Dimopoulos, Christopher Farthing, Martin Gill, Piotr Graczyk, Anthony Groom, Thomas Horstmann, Atsushi Inoue, Afzal Khan, Hugh Malkin, Darren Medland, Louise Morgan, Kenzo Muramoto, Stephen Neame, Hirotoshi Numata, Makoto Ogo, Vanessa Palmer, Jonathan Papworth, Toshal Patel, Masahiro Sakurai, Edgar Schuck, Bina Shah, James Staddon, Susumu Takakuwa, Osamu Takenaka, Naoki Tokuhara, Nancy Wong, Toshihiko Yamauchi.
 355Identification of a TYK2 selective lead series
Steven Magnuson,
 356Benzthiazoles as leukotriene A4 hydrolase inhibitors
Genesis M Bacani,
 357Novel scaffold replacement methodology applied to the discovery of P38 MAP kinase inhibitors
Nels Thorsteinson, Christopher Williams.
 358Novel phosphate prodrugs of N-acetyl-(D)-glucosamine for the treatment of osteoarthritis
Michaela Serpi, Rita Bibbo, Helen Roberts, Claire Hughes, Bruce Caterson, María José Alcaraz, Anna Torrent Gibert, Carlos Raul Alaez Verson, Christopher McGuigan.
 359Synthesis of new positron emission tomography (PET) radioligands for PDE10 imaging: In vivo evaluation of [18F]MNI-654 and [18F]MNI-659 in nonhuman primate
G. D. Tamagnan, D. Thomae, D. Alagille, S. Lee, O. Barret, R. M. Baldwin.
 360Synthesis and biological evaluation of tetrabenazine derivatives for brain vesicular monoamine transporter VMAT2 imaging
Caroline Papin, David Alagille, Sharon Lee, Olivier Barret, Ronald M Baldwin, Gilles Tamagnan.
 361Pharmacophore based 3D-QSAR, homology modeling, docking studies and microwave-assisted synthesis of some novel triazolothienopyrimidines as possible adenosine receptors antagonists
Rajwinder Kaur, Pran Kishore Deb, Venkat Rao Kaki, Balakumar Chandrashekaran, Raghuram Rao Akkinepalli.
 362Highly potent and selective fluorescent antagonist of the adenosine A3 receptor: Use as an imaging tool
Andrea J Vernall, Leigh A Stoddart, Stephen J Briddon, Stephen J Hill, Barrie Kellam.
 363Discovery and characterization of novel small molecule inhibitors of Abeta1-42 for the treatment of Alzheimer's disease
Nampally Sreenivasachary, Heiko Kroth, Cotinica Hamel, Pascal Benderitter, Wolfgang Froestl, Yvan Varisco, Kevin Poupard, Paolo Paganetti, Andrea Pfeifer, Andreas Muhs.
 364Development of chalcone-based apoE modulators through structure-activity relationship (SAR) study
Martin A Leon, Charles E Mordaunt, Mandeep Singh, Jason A Welles, Jason T Schott, Anthony J Vargas, Nilay V Patel, Santanu Maitra.
 365Development of apoE inhibitors by structure-activity relationship (SAR) study on triarylamine compounds
Mandeep Singh, Jason T Schott, Martin A Leon, Robert T Granata, Charles E Mordaunt, Anthony J Vargas, Nilay V Patel, Santanu Maitra.
 366Structural modification of (-)-N6-(2-(4-(biphenyl-4-yl)piperazin-1-yl)-ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (D-264): An effort to improve the blood brain barrier crossing ability and multifunctional property in lead compounds for the treatment of Parkinson's disease
Gyan Modi, Tamara Antonio, Maarten Reith, Aloke Dutta.
 367Structure activity relationships (SAR) of 3-chloro-3'-((2-cyclopentyl-3-oxo-2,3-dihydrobenzo[d]isothiazol-6-yloxy)methyl)biphenyl-4-carboxylic acid analogs that are metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulators
Dhanya Raveendra-Panickar, Douglas Sheffler, Hilary Highfield Nickols, Manoranjan D'Souza, Li Yang, Russell Dahl, Svetlana Semenova, Athina Markou, Jeffrey Conn, Nicholas D.P. Cosford.
 368Design, synthesis, and evaluation of novel metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulators (PAMs): Refinement of SAR
Shyama Sidique, Douglas Sheffler, Hilary Highfield Nickols, Manoranjan D'Souza, Li Yang, Russell Dahl, Svetlana Semenova, Athina Markou, Jeffrey Conn, Nicholas D. P. Cosford.
 369Computational studies of conotoxins as nicotinic acetylcholine receptor (nAChRs) antagonists
Conrad A Rohleder, Colten K Rohleder, Kelsi T Nervik, Taya M Treulieb-Kolostyak, Veronica M Shaner, Somisetti V Sambasivarao, C Mark Maupin.
 370Thiazolo[4,5-d]pyrimidines and 5-(alkylthio)-4-(arylamino)pyrimidine derivatives as corticotropin releasing factor receptor 1 (CRFR1) antagonists
Bhimanna K Kuppast, Pawel Szymanski, Yueshan Hu, Gareth E Davies, George Liapakis, Hesham Fahmy.
 371Development of drug-like small molecule group II metabotropic glutamate receptor (mGluR) positive allosteric modulators (PAMs) having differential selectivity: Discovery of mGluR PAMs possessing either selective or balanced mGluR2/mGluR3 activity
Russell Dahl, Li Yang, Melinda Davis, Douglas Sheffler, Santhi Ganji, Svetlana Semenova, Athina Markou, P. Conn, Nicholas D. P. Cosford.
 372Heterocycle-fused 4-phenyl tetrahydroisoquinolines as dual NET/DAT inhibitors
Shuang Liu, Anthony D. Pechulis, James P. Beck, Zhicai Yang, A. Samuel Vellekoop, Mark P. Sweet, Arthur E. Harms, Mark A. Wolf, Carla Hassler, Andrew M. Klos, Chester J. Opalka, Peter J. Crocker, Mark A. Smith, Bruce M. Molino.
 373Synthesis and identification of fluorinated (2S,4R,5R)-2-(bis(4-fluorophenyl)methyl)-5-((4-hydroxybenzyl)amino)tetrahydro-2H-pyran-4-ol, 4-((((3S,6S)-6-(bis(4-fluorophenyl)methyl)tetrahydro-2H-pyran-3-yl)amino)methyl)phenol and analogs thereof as new generation triple uptake inhibitors for antidepression therapy
Soumava Santra, Sanjib Gogoi, Solav Ali, Marteen D Reith, Aloke Dutta.
 374Structure-activity relationship studyof the neuroprotective effects of Vitamin K derivatives
Ben Josey, James Chou.
 375Synthesis and evaluation of clickable active site-directed γ-secretase photoaffinity probes
Christopher W am Ende, Christina J Crump, T. Eric Ballard, Martin Pettersson, Nikolay Pozdnyakov, Kelly R Bales, Yue-Ming Li, Douglas S Johnson.
 376Structure activity relationship study of N6-(2-(4-(1H-indol-5-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine analogs: Development of highly selective D3 dopamine receptor agonists and their pharmacological characterization
Mark A Johnson, Tamara Antonio, Maarten E. A. Reith, Aloke K. Dutta.
 377Further structure activity relationship studies of 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol and its analogs: Identification of novel triple uptake inhibitors as new generation antidepressants
Bhaskar Gopishetty, Solav Ali, Marteen E. A. Reith, Aloke K. Dutta.
 378Neuroprotective activities of a common structural motif in neuroprotective natural products
Jehad S Almaliti, Anusha Madineni, Shadia Nada, Zahoor A Shah, L. M. Viranga Tillekeratne.
 379Identification of highly potent and selective dopamine D3 ligands
Jianyong Chen, Gregory T. Collins, Beth Levant, James Woods, Shaomeng Wang.
 380Novel 6-aminonicotinic acids as γ-aminobutyric acid receptor ligands: Synthesis, pharmacology, and modeling
Jette G Petersen, Pernille L Sørensen, Birgitte Nielsen, Anders A Jensen, Thomas Balle, Bente Frølund.
 381WITHDRAWN
 382Development of high affinity, highly selective agonist ligands for positron emission tomography imaging of the dopamine D2 receptor
Anna W. Sromek, John L. Neumeyer, Yu-Gui Si, Tangzhi Zhang, Philip Seeman, Susan R. George, Lars Farde, Christer Halldin, Vladimir Stepanov, Sjoerd Finnema.
 383Fully automated synthesis of PET TSPO radioligands [11C]DAA1106 and [18F]FEDAA1106
Min Wang, Mingzhang Gao, Qi-Huang Zheng.
 384Synthesis, structural characterization and in vitro antimicrobial activity of Pd(II) complexes incorporating ligand, 2-(2-thienyl)2,3-dihydro-1H-perimidine
Saud I Al-resayes, Mohammad Azam.
 385Novel nitrotriazole-based amides and sulfonamides as potential antitrypanosomal drugs.
Maria Papadopoulou, William D. Bloomer, Eric Chatelain, Marcel Kaiser, Shane R. Wilkinson, Jean-Robert Loset.
 386Conformation of the diacetate of virginiamycin m1 (pristinamycin IIa, streptrogramin a)
Isabelle Nevchas Lerario, Mikael Bergdahl, Carl J Carrano, Frances Separovic, Robert P Metzger.
 387Synthesis and evaluation of novel trisubstituted benzimidazoles targeting FtsZ as antimicrobial agents
Bora Park, Kunal Kumar, Divya Awasthi, Eduard Melief, Jason Cummings, Richard A Slayden, Iwao Ojima.
 388Synthesis and biological evaluation of novel antitubercular trisubstituted benzimidazoles and C-seco taxoids targeting FtsZ
Divya Awasthi, Bora Park, Kunal Kumar, Eduard H Melief, Susan Knudson, Richard A Slayden, Iwao Ojima.
 389Synthesis, biological evaluation, and molecular modelling studies of some novel 1,3,5-triazine analogs
Sonika Jain, Jaya Dwivedi, Dharma Kishore.
 390Mechanism of action and inhibition of head-to-head and head-to-tail prenyl synthases
Yi-Liang Liu, Fu-Yang Lin, Yonghui Zhang, Ka Li, Joo-Hwan No, Fernando de M. Dossin, Wei Zhu, Ran Pan, Xinxin Feng, Rong Cao, Ke Wang, Raymond Hui, Lucio H. Freitas-Junior, Eric Oldfield.
 391Synthesis of erythrosine and rosebengal based photosensitizers for photodynamic antimicrobial chemotherapy
Hari Prasad Reddy Mangunuru, Anthony De Lucca, Guijun Wang.
 392Dual functionalized 2'β-substituted-6β-(hydroxymethyl)penicillin sulfones as inhibitors of β-lactamase
Micheal Nottingham, Christopher R Bethel, Elizabeth Rodkey, Daniel Fernandez, Kay Dannenmaier, Revanth Manchenella, RuchithaRuhi Thalakola, Paul R Carey, Robert A Bonomo, Focco van den Akker, John D Buynak.
 393Aminopyrimidine kills Mycobacterium tuberculosis by inhibition of decaprenylphosphoryl-β-d-ribose 2′-epimerase
Eugene Uh, Xinxin Yang, Helena I Boshoff, Clifton E Barry III.
 394Design, synthesis and biochemistry evaluation of novel (E)-Cinnamic N-acylhydrazone antichagasic candidates
Gustavo Henrique Goulart Trossini, Elizabeth Igne Ferreira, Samir Carvalho, Larisse Feitosa, Maria Henriques, Kelly Salomão, Solange Castro, Marcel Kaiser, Reto Brun, James Wardell, Solange Wardell, Edson F da Silva, Thadeu Costa, Adriano Defini Andricopulo, Carlos Alberto Manssour Fraga.
 395Virtual screening strategies for the discovery of new inhibitors of Trypanosoma brucei aldolase
Leonardo L G Ferreira, Rafaela S Ferreira, Otavio H Thiemann, Adriano D Andricopulo.
 396Synthesis and modification of natural sterols possessing antileishmanial activity
Dalia Abdelhamid, Li Pan, Claudio M Lezama-Davila, Abhay Satoskar, A.Douglas Kinghorn, James R Fuchs.
 397Antifungal activity of semisynthetic β-1,3-glucan synthase (GS) inhibitors
M. Peel, G. Pacofsky, W. Fan, A. Mamai, K. Nelson, J. Balkovec, A. Flattery, R. Giaccobe, J. Nielsen-Kahn, P. Liberator.
 398Semisynthetic β-1,3-glucan synthase (GS) inhibitors with potent antifungal activity
M. Peel, W. Fan, G. Pacofsky, A. Mamai, J. Hong, G. Ouvry, J. Balkovec, G. Abruzzo, A. Flattery, R. Giacobbe, C. Gill, M. -J. Hsu, F. Racine, P. Liberator, J. Nielsen-Kahn.
 399Discovery of antimicrobial agents for α-subunit of tryphtophan synthase: Protein conformational sampling, docking and experimental assays
Rizi Ai, So-Ning Lee, Wai M Thant, Michael F Dunn, Shih-hsin Kan, Dimitri Niks, Chia-en A Chang.
 400Synthesis and evaluation of novel saponin barbiturates as antifungal compounds
Monika Madhav, Amy Cammarata, Branko S Jursic, Donna M Neumann.
 401Understanding cephalosporin-derived inhibitors of β-lactamase
Jacqueline Sifuentes, Micheal Nottingham, David McLeod, Weirui Chai, Christopher R Bethel, Elizabeth Rodkey, Robert A Bonomo, Focco van den Akker, John D Buynak.
 402Novel benzoxaboroles as a new class of ß-lactamase inhibitors
Yi Xia,
 403Benzoic acids target both cis- and trans-prenyl transferases: A crystallographic investigation
Wei Zhu, Yonghui Zhang, Yi-Liang Liu, Rong Cao, Joo-Hwan No, Fu-Yang Lin, Kai Li, Ke Wang, Kevin Houlihan, Anna Sankovsky, William Sinko, César Augusto F. de Oliveira, J. Andrew McCammon, Eric Oldfield.
 404Synthesis of unsymmetrical cyclotriazadisulfonamide (CADA) analogs as specific T-lymphocyte CD4 receptor down-modulating agents
Chiraphorn Khan, Dominique Schols, Kurt Vermeire, Thomas W. Bell.
 405Synthetic CCR5-derived peptides that inhibit HIV entry
Cajetan Dogo-Isonagie, Son Lam, Priyamvada Acharya, Peter Kwong, Carole Bewley.
 406Synthesis of novel cada analog prodrugs designed to act as anti-hiv agents via down-modulation of the cd4 receptor
Emily D Scarbrough, Dominque Schols, Kurt Vermeire, Thomas Bell.
 407Development of anticoxackievirus agents targeting 3C protease
Bo-Kyoung Kim, Joong-heui Cho, Na-Ri Kim, Pyeonghwa Jeong.
 408Convergent synthesis of phosphonate analogs bearing a biolabile moiety
Luigi A Agrofoglio, Ugo Pradere, Vincent Roy, Manabu Hamada, Ozkan Sari.
 409Design and synthesis of imidazopyridine compounds as potent HCV antiviral agents
Anna L Banka, John B Shotwell, Andrew J Peat, John G Catalano, Pek Y Chong, Vincent Tai, Dulce M Garrido, John Miller, Huichang Zhang, Michael Youngman, Jeffrey J Pouliot, Zhiping Xiong, Amanda M Mathis.
 410Inhibitors of West Nile Virus protease based on the isoindolin-1-one scaffold
Sridhar Aravapalli, Dengfeng Dou, Tzutshin Wong, Christopher S Groutas, Tadahisa Teramoto, Padmanabhan R, William C Groutas.
 411Synthesis of novel sultams, a family of non-nucleoside reverse transcriptase inhibitors
Brian C LeCroix, Riyam Kafri, Jianmin Mao, Andy Rowe, David C Baker.
 412Discovery and development of sulfonylpyrrolidine compounds that inhibit human respiratory synctial virus activity
Daljit S Matharu, James W Noah, William Severson, Donghoon H Chung, Blake Moore, Fuli Jia, Xiaolin Xu, Clinton Maddox, Lynn Rasmussen, Melinda I Sosa, Nichole A Tower, Sampath Ananthan, Lucile White, Colleen Jonsson, Jennifer E Golden, Jeff Aubé.
 413Synthesis and evaluation of gallic acid derivatives as potential therapeutic targets
Mamta Sachdeva, M Karan, T Singh, R. Chadha, P.D. Sharma.
 414Luciferase gene transfection mediated by cationic liposomes comprising novel trans-2-aminocyclohexanol-based amphiphiles
Xin Liu, Yu Zheng, Nataliya M Samoshina, Andreas H Franz, Vyacheslav V Samoshin, Xin Guo.
 415Efficient cellular delivery of methotrexate by liposomes containing novel amphiphiles with pH-triggerable conformations
Nataliya M Samoshina, Xin Liu, Yu Zheng, Andreas H Franz, Xin Guo, Vyacheslav V Samoshin.
 416Synthesis-based design: A holistic approach to lead development
Kevin J. Gaffney, Jamie A. Jarusiewicz, Marcos A. Sainz, Kalyan Nakulapalli Venkata, Nicos A. Petasis.
 417Rational design, synthesis, and biological analysis of GPR55 antagonists
Mary A Lingerfelt, Haleli Sharir, Dow Hurst, Mitchell P Croatt, Mary E Abood, Patricia Reggio.
 418Discovery of triazolopyridines as potent and selective acyl-CoA: Diacylglycerol acyltranferase 1 (DGAT1) inhibitors
Chongqing Sun, Yanting Huang, Huji Tuerdi, Hannguang Chao, Tara Peterson, Jessica Dong, Ching-Hsuen Chu, Zhengping Ma, Luping Chen, Ramakrishna Seethala, Susan Harvey, Helen Godonis, Suzanne Rooney, James Devenny, Maryann Pelleymounter, Hong Cai, Aberra Fura, William Ewing, Michael Poss, Dong Cheng, R. Michael Lawrence.
 419Discovery and initial SAR of potent antagonists of NPBWR1 (GPR7)
Zhiqiang Guo, Anthony Romero, Nicholas Hastings, Remond Moningka, Ming Wang, Jerry Di Salvo, Qiaolin Deng, Vincent Tong, Jenna Terebetski, Richard G. Ball, Petr Vachal, Feroze Ujjainwalla.
 420Discovery of potent dihydrocinnamic acids as free fatty receptor 1 (FFA1/GPR40) agonists
Elisabeth Christiansen, Maria E. Due-Hansen, Christian Urban, Nicole Merten, Johannes Schmidt, Susanne Ullrich, Evi Kostenis, Matthias Kassack, Trond Ulven.
 421Synthesis of alkoxyalkyl esters of 5-fluorouridine-3ʹ,5ʹ-cyclic monophosphate: Intravitreal prodrugs for sustained drug release to the posterior segments of the eye
James R. Beadle, Lingyun Cheng, Karl Y. Hostetler, William R. Freeman.
 422Frontal analysis for characterization of binding sites in molecularly imprinted polymer of adenosine 5'-monophosphate: A biomimetic sensor of nucleoside phosphorylation mediated by adenylate kinase
Luigi A Agrofoglio, Kinga Puzio, Raphael Delepee.
 423Pyridopyrimidinone analogs as orally efficacious GPR119 agonists
Santhosh F Neelamkavil, Craig D Boyle, Samuel Chackalamannil, Andrew W Stamford, William J Greenlee, Hana Baker, Brian Hawes, Timothy Kowalski, Kim O'Neill.
 424Carboxylic acid bioisosteres in free fatty acid receptor 1 (FFA1/GPR40) agonists
Maria E. Due-Hansen, Christian Urban, Matthias U. Kassack, Trond Ulven.
 425Discovery of potent and selective GPR120 agonists
Bharat Shimpukade, Brian Hudson, Christine Kiel Hovgaard, Graeme Milligan, Trond Ulven.
 426Rational design, synthesis, and structural characterization of D-Phe-Pro-D-Arg-derived thrombin inhibitors
Cristina C. Clement, Ana Carvalho Figueiredo, Zakia Sheuli, MAnfred Philipp, Pedro José B Pereira.
 427Synthesis and pharmacology of a potent and orally active CETP Inhibitor, (-)-K-18597
Tadaaki Ohgiya, Koichi Yamazaki, Kimiyuki Shibuya, Toru Miura, Ayumu Okuda, Toshiharu Arai, Taro Aoki, Katsutoshi Miyosawa, Ken Mizuno, Takeshi Murakami, Kentaro Murakami, Sohei Tanabe.
 428WITHDRAWN
 429Design, synthesis, and evaluation of some novel hetero-fused pyrimidines as possible adenosine receptor antagonists
Pran Kishore Deb, Venkat Rao Kaki, Rajwinder Kaur, Raghu Prasad Mailavaram, Raghuram Rao Akkinepalli, Balakumar Chandrashekaran, Lakshmi Narayana Bhimanapally, Payal Jain, Kunal Roy, Murthy Debarakonda.
 430Rational development of reversible inhibitors of the Vitamin D receptor-coregulator interactions
Kelly Teske,
 431Rapid purification of a diverse range of peptides using flash chromatography with ELSD and UV detection
Melissa J Wilcox, Jeff Horsman, Kathryn Lawrence, Shahnaz Ghassemi.
 432WITHDRAWN
 433Advanced detection techniques for flash chromatography
Jack E. Silver, Paul Bellinghausen, Nancy Fowler.
 434WITHDRAWN
 435Improvement in solubility of bicyclic molecules focusing on dihedral angle and symmetry
Minoru Ishikawa, Yuichi Hashimoto.
 436Site-directed mutagenesis of intrinsic factor and its potential use as a drug delivery agent
Debbie Valentin, Robert P. Doyle.
 437Method development for equilibrium and kinetic binding in vitro bioequivalence of colesevelam hydrochloride in simulated intestinal fluid (SIF)
Adam C Myers, Josef K Ludwig, Jennifer L Sassman, Jonathan W Henry, Yinyan Zhao.
 438Precise delivery of active molecules(drugs) using diode laser
Moses Bio, Gregory Nkepang, Youngjae You.
 439Interaction of nucleic acids with the glycocalyx
Michael J Palte, Ronald T Raines.
 440Synthesis, in vitro, and in vivo biology of dual-targeting DNA supercoiling inhibitors for the treatment of bacterial infections
James T. Palmer, Stephanie Barker, James M. Bennett, Michael Blair, David R. Brown, Lloyd G. Czaplewski, Ian Collins, David T. Davies, David J. Haydon, Paul Lancett, Alastair Logan, Christopher J. Lunniss, Leanne MacLeod, Gary R.W. Pitt, Stéphanie Pommier, Daniel Price, Neil R. Stokes, Helena B. Thomaides-Brears.