MEDI Joel Barrish  Wednesday, April 10, 2013 

417 - High-density lipoprotein-based theranostic nanoparticle platform for atherosclerosis

Sean Marrache,, Shanta Dhar. Department of Chemistry, University of Georgia, Athens, GA 30602, United States

Atherosclerosis continues to be one of the leading causes of death in the United States despite numerous advances in treatment and prevention. There is growing interest in the early identification and treatment of vulnerable plaques, which are at high risk of disruption followed by thrombosis. However, there is no accepted method for the early detection of such plaques. Here we present a high-density lipoprotein (HDL)-mimicking nanoparticle (NP) for the detection of apoptotic macrophages in vulnerable plaques by targeting the mitochondrial membrane collapse that occurs during apoptosis. These HDL-mimicking NPs demonstrate excellent biocompatibility, serum stability, physicochemical, and non-immunogenic properties, which prove to be promising for future clinical imaging of apoptosis in vulnerable plaque for its early diagnosis. They are also potentially suitable for rerouting cholesterol away from plaque macrophages to help prevent or slow the progression of vulnerable plaque. In vitro sensing as well as in vivo biodistribution and pharmacokinetics will be discussed.

Wednesday, April 10, 2013 07:00 PM
General Poster Session (07:00 PM - 10:00 PM)
Location: Morial Convention Center
Room: Hall A


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