PMSE Alshakim Nelson, Matthew Becker, Sergio Granados-Focil, Christopher Stafford  Tuesday, March 18, 2014 

259 - Facile fabrication of “Dual Click” 1- and 2D orthogonal concentration gradients for stem cell differentiation direction

Yanrui Ma, ym7@zips.uakron.edu, Matthew L Becker. Department of Polymer Science, The University of Akron, Akron, OH 44325, United States

The spatial presentation and concentration of surface function is often crucial for successful material function design. For the surface mimic and function studies, self-assembled monolayers (SAMs), that have easily tunable functions and wide variety of suitable reaction chemistries, provide a suitable strategy. Furthermore, combined with high-throughput combinatorial strategies, SAMs gradient surfaces, which can surveying a wide range of materials parameters in limited experimental trials and short time, enable the rapid, efficient and precise investigation of surface properties. In our study, we designed a novel “vacuum away” confined channel vapor deposition method, which is simple and easily controllable, and linear gradient chemical concentration profiles with tunable chemical functionalities were generated on silicon and glass substrates. In addition, two-dimensional (2D) orthogonal chemical concentration gradients were achieved by using a sequential deposition protocol which enables the orthogonal engineering of functional SAMs.

This method is highly useful in the investigation of cooperative interactions of surface active species. One such combination of interest is the synergistic influence of cell adhesion arginine-glycine-aspartic acid (RGD) sequences and bone morphogenetic protein(BMP-2), which would potentially enhance the stem cell adhesion while promote proliferative and osteogenic activity.



Tuesday, March 18, 2014 05:30 PM
Joint PMSE/POLY Poster Session (05:30 PM - 07:30 PM)
Location: Dallas Convention Center
Room: Hall A

 

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