PMSE Alshakim Nelson, Matthew Becker, Sergio Granados-Focil, Christopher Stafford  Tuesday, March 18, 2014 

280 - Hydroxyapatite-targeting dendrons and its application as osteoinductive peptide sequestering

Wen Tang, wt5@zips.uakron.edu, Geng Hua, Jinjun Zhou, Fei Lin, Jukuan Zheng, Matthew Becker. Department of Polymer Science, The University of Akron, Akron, OHIO 44325, United States

Osteoinductive peptides that induce the bone formation are attractive to apply in developing new generation of bone implants that not only provide mechanical support but also promote new bone formation. However, how to immobilize peptides onto the bone implants surface, hydroxyapatite (HA) in most cases, efficiently and easily remains an issue that requires more efforts to dedicate to. Here we proposed to use a catechol functionalized dendron as the HA-targeting moiety, and conjugate the dendron with osteoinductive peptides through simple amidation reaction to obtain a modular molecule that one part strongly binds with HA, the other part interacts with the cells and induce new bone formation. The relationship between catechol number and binding affinity to HA was studied with quartz crystal microbalance with dissipation (QCM-D) to optimize the dendron structure. And the osteoinductivity of peptides after covalently linked to the dendron was evaluated by biological experiments in vitro.


Tuesday, March 18, 2014 05:30 PM
Joint PMSE/POLY Poster Session (05:30 PM - 07:30 PM)
Location: Dallas Convention Center
Room: Hall A

 

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