PMSE Alshakim Nelson, Matthew Becker, Sergio Granados-Focil, Christopher Stafford  Tuesday, March 18, 2014 

301 - Drug eluting electrospun rubbery fiber mats

Aditya Jindal1, aj58@zips.uakron.edu, Andrea Charif2, John Friess2, Judit E. Puskas1,2. (1) Department of Chemical and Biomolecular Engineering, The University of Akron, Akron, Ohio 44325-3906, United States, (2) Department of Polymer Science, The University of Akron, Akron, Ohio 44325-3909, United States

This work reports release studies of acetylsalicylic acid (Aspirin), a model drug from electrospun ArbomatrixTM {a block copolymer with arborescent polyisobutylene (PIB) core and poly (para-methyl styrene) PMS end blocks} polymer fiber mats. ArbomatrixTM –PEG polymer solutions containing 15 and 30 wt% Aspirin were electrospun onto parchment paper to yield free-standing rubbery fiber mats. Aspirin release into phosphate buffered saline (PBS) solution (pH = 7.4) at 37oC was measured by UV spectroscopy. In three days 42 and 90% of the loaded Aspirin was released from the mats containing 15 and 30wt% Aspirin, respectively. Due to the excellent biocompatibility of ArbomatrixTM these mats hold great promise for drug delivery applications.


Tuesday, March 18, 2014 05:30 PM
Joint PMSE/POLY Poster Session (05:30 PM - 07:30 PM)
Location: Dallas Convention Center
Room: Hall A

 

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