POLY Scott Iacono, Dylan Boday, Jeffrey Youngblood  Wednesday, March 19, 2014 

579 - Modular surface functionalization of polyisobutylene-based thermoplastic elastomers

Alejandra Alvarez Albarran1, aa88@zips.uakron.edu, Judit E. Puskas1,2, Lingyun Liu2. (1) Department of Polymer Science, The University of Akron, Akron, Ohio 44325, United States, (2) Department of Chemical and Biomolecular Engineering, The University of Akron, Akron, Ohio 44325, United States

The Puskas group proposed to modify the surface properties of polyisobutylene (PIB)-based thermoplastic elastomers (TPEs) using a modular approach. PIB-based TPEs are emerging biomaterials; the first generation is used as the drug-eluting coating on coronary stents. The surface chemistry of PIB-based TPEs can be modified using this modular approach by “gluing” low molecular weight functionalized PIBs (PIB-X) to the surface of the TPEs. PIB-OH was made by living carbocationic polymerization using propylene oxide as initiator and titanium tetrachloride (TiCl4) as coinitiator. PIB-PEG was then synthesized from PIB-OH using Candida antartica Lipase B (CALB) as catalyst and spin coated onto the surface of a TPE. Protein adsorption studies using Surface Plasmon Resonance (SPR) demonstrated decreased fibrinogen adsorption to the modified surface. This modular approach is much simpler than attaching functional groups covalently to surfaces, therefore it holds great promise in practical applications.

Wednesday, March 19, 2014 10:40 AM
General Topics: New Synthesis and Characterization of Polymers (08:00 AM - 12:00 PM)
Location: Hyatt Regency Dallas
Room: Reverchon A/B


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