MEDI John Macor  Sunday, March 16, 2014 

147 - Mitochondria-targeted nanoparticle assisted activation of dendritic cells for immune boosting treatment of breast cancer

Sean Marrache1, sm186@uga.edu, Shanta Dhar1,2. (1) Department of Chemistry, University of Georgia, Athens, GA 30606, United States, (2) Department of Physiology and Pharmacology, University of Georgia, Athens, GA 30606, United States

Photodynamic therapy (PDT) is an anti-cancer treatment that involves the administration of a photosensitizer (PS) followed by the irradiation by long-wavelength light. This leads to tumor cell destruction and induction of the host cell immune through the generation of reactive oxygen species. However, much optimization is needed in order to reach PDT's full potential to boost the host immune system. We speculated that by delivering the PS preferentially to its target organelle, the mitochondria, the result would be more efficient cancer cell apoptosis and immune system boosting. Recently, we developed a mitochondria-targeted polymeric nanoparticle (NP) platform that has the ability to deliver a wide array of payloads to the mitochondria.1 Here, we report the potential of MCF-7 breast cancer cell antigens derived from mitochondria-targeted delivery of zinc phthalocyanine (ZnPc) using our NP system followed by light activation with a long wavelength laser of these cells in activating dendritic cells (DCs).2 The tumor antigens generated were found to induce DC maturation and production of interferon-gamma.2



References:

1) Marrache, S. and Dhar, S. Engineering of Blended Nanoparticle Platform for the Delivery of Mitochondria-Acting Therapeutics. Proc. Natl. Acad. Sci. U.S.A. 2012 , 109, 16288-16293.

2) Marrache, S.; Tundup, S.; Harn, D.A.; Dhar, S. Ex Vivo Programming of Dendritic Cells by Mitochondria-Targeted Nanoparticles to Produce Interferon-Gamma for Cancer Immunotherapy. ACS Nano, 2013 , 7392–7402.


Sunday, March 16, 2014 07:00 PM
General Poster Session (07:00 PM - 10:00 PM)
Location: Dallas Convention Center
Room: Hall E


Monday, March 17, 2014 08:00 PM
Sci-Mix (08:00 PM - 10:00 PM)
Location: Dallas Convention Center
Room: Hall F

 

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